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Glycolysis converts the 13 C-glucose tracer to M3-pyruvate isotopologues which are oxidized to M2-acetyl-CoA by PDC and finally condensed with oxaloacetate to M2-citrate

While acetaminophen itself does not produce cravings or compulsive drug-seeking behavior, its presence in opioid formulations contributes to prolonged misuse, increasing the likelihood of opioid addiction

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